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Minimum Cost
$ 17000
Maximum Cost.
$ 30000
- Days In Hospital 10 days
- Outside Hospital Stay 30 days
- Success Rate 82%
Overview of Pediatric Bone Marrow Transplant in India
A paediatric bone marrow transplant is a treatment used for children with blood cell abnormalities or cancer. Diseased bone marrow is used in bone marrow transplants to replenish the stem cells. Healthy stem cells that develop into white blood cells, red blood cells, and platelets are produced by the bone marrow under normal circumstances.
However, in an illness, the bone marrow creates aberrant cells, which may necessitate a bone marrow transplant. The disease's symptoms change based on the child's particular condition. For a long time, some kids who have severe symptoms will require a bone marrow transplant to survive.
The first step in the bone marrow transplant procedure is typically selecting a suitable donor, who can be an unrelated person or a compatible family member. Nonetheless, it is normally favoured if the donor is a close relative.
Following the identification of a donor, the kid has radiation therapy or chemotherapy to eradicate the bone marrow's cancerous cells. The injured stem cells are then replaced with healthy stem cells through transplantation. The donor's compatibility, post-transplant care, and the child's general health before the procedure all affect the success of paediatric bone marrow transplants.
In India, paediatric bone marrow transplants can cost anywhere between $18,000 and $60,000. The cost of the transplant operation might be affected by the donor chosen before the procedure. The total cost of the process may also be impacted by the requirement for supporting treatments, such as blood transfusions, medications to prevent infection and rejection, and nutritional support.
What Is A Bone Marrow Transplant For Children?
Certain cancers and other illnesses can be treated in children using bone marrow transplants (BMTs). BMT aims to replace a child's damaged bone marrow with healthy bone marrow.
All blood cell types, including stem cells, are produced in the spongy substance called bone marrow, which is located in the middle of bones. BMT involves filtering stem cells before reintroducing them into the same infant. Or they are placed in a different ill child. New, healthy bone marrow will develop from these stem cells. The term "graft" refers to transplanted stem cells.
Types of Pediatric Bone Marrow Transplant:
Autologous Transplant
This method involves removing and preserving a child's stem cells before cancer treatment. The body will recognise and accept its cells, thus there is a lower chance of rejection with this individualised method.
Allogeneic Transplant
The process of an allogeneic transplant uses stem cells from a suitable donor, usually a relative or an unrelated match. The likelihood of discovering a compatible match is increased by using this method. For the paediatric bone marrow transplant process to be successful, a suitable match is essential.
Haploidentical Transplant
The donor for the haploidentical transplant is partially matched to the child. This method is beneficial in situations where there isn't a fully matched donor. It is an alternate method of performing a bone marrow transplant in children.
Umbilical Cord Blood Transplant
Stem cells are extracted from the newborn's umbilical cord using this method. This procedure provides a different transplant source. Compared to traditional donors, umbilical cord blood transplants are more readily available and have a lower rate of rejection.
Reduced-Intensity Transplant
With this method, low-intensity treatments are administered in small doses to eradicate the diseased bone marrow instead of heavy doses of radiation therapy or chemotherapy. In circumstances involving children who might not be able to handle the high dosages involved in conventional transplants, this method is especially appropriate.
Procedure:
The following is a summary of the paediatric bone marrow transplant process:
Donor Selection: The person from whom the stem cells are extracted is chosen. Umbilical cord blood donors, unrelated but matched donors, or compatible family members should all be considered.
Conditioning regimen: To make room for the transplant and remove any existing bone marrow, chemotherapy or radiation therapy is administered before the transplant process.
Harvesting Stem Cells: Bone marrow aspiration, peripheral blood stem cell apheresis, or umbilical cord blood banking are the methods used to obtain the donor stem cells.
Transplantation: With a central venous catheter, the stem cells are injected into the child's circulation following collection. This enables the stem cells to move to the bone marrow and create a new system for producing blood cells.
Engraftment Monitoring: Following a transplant, blood counts must be regularly checked to see whether donor cells have successfully engrafted into a child's bone marrow.
Immunosuppression: To prevent the recipient cells from rejecting the donor cells, some drugs are given to a child to suppress their immune system.
Supportive Care: To manage side effects and promote healing, patients undergoing a paediatric bone marrow transplant receive supportive care after the procedure, which includes blood transfusions, infection-control medications, and nutritional support.
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Cost of Pediatric Bone Marrow Transplant in India
Paediatric Bone Marrow Transplant Cost In Different Parts of India
|
Cities |
Starting Price |
|
Delhi |
USD 18000 |
|
Gurgaon |
USD 18000 |
|
Noida |
USD 18000 |
|
Mumbai |
USD 18200 |
|
Hyderabad |
USD 18100 |
|
Chennai |
USD 18000 |
|
Kolkata |
USD 18000 |
|
Bangalore |
USD 18300 |
Cost of Different Pediatric Bone Marrow Transplant in India
|
Treatment Costs in India |
Min in USD |
Max in USD |
|
Autologous Bone Marrow Transplant |
18000 USD |
22000 USD |
|
Allogeneic Bone Marrow Transplant |
30000 USD |
38000 USD |
|
Haplo–Allogeneic Bone Marrow Transplant |
42000 USD |
52000 USD |
Factors That Can Affect Paediatric Bone Marrow Transplant Cost in India
The following factors may influence the cost of a paediatric bone marrow transplant in India:
- The cost of medication.
- Length of the therapy.
- Geographical position.
- Costs associated with hospitalisation.
- Government subsidies and policies.
- Packages for medical tourism.
- Hospital infrastructure and repute.
- The knowledge and experience of health care providers.
- The kind and regularity of diagnostic tests.
- The method of therapy was selected.
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Indications of Pediatric Bone Marrow Transplant:
Why Would A Child Need A Bone Marrow Transplant?
- BMT aims to cure a variety of illnesses, including some forms of cancer. It can be applied to:
- Substitute healthy bone marrow for sick bone marrow. Leukaemia, sickle cell anaemia, and aplastic anaemia are among the diseases for which this is done.
- After receiving significant amounts of radiation or chemotherapy to treat cancer, the bone marrow is affected. Rather than being called a transplant, this procedure is often referred to as a rescue. Diseases such as neuroblastoma and lymphoma are treated in this manner.
- To stop further harm from a hereditary illness, replace the bone marrow with healthy bone marrow. This is done to treat conditions like adrenoleukodystrophy disorder and Hurler syndrome.
Diseases That Can Be Treated With BMT
- Cancers like brain tumours, kidney cancer, rhabdomyosarcoma, neuroblastoma, leukaemia, and lymphoma
- Aplastic anaemia
- Wiskott-Aldrich disease and severe combined immunodeficiency are examples of immune deficiencies.
- Genetic illnesses, including adrenoleukodystrophy disorder, Hurler syndrome, Diamond Blackfan anaemia, thalassaemia, and sickle cell disease
Risk Factors:
Some of the dangers associated with a bone marrow transplant are potentially fatal. Before the treatment, the BMT team and your child's healthcare physician will go over the advantages and disadvantages.
- Complications and risks could differ depending on:
- The kind of BMT
- The illness that the transplant is intended to treat
- Which medications are prescribed before the transplant
- The age and general health of your child
- The variations in the recipient's and donor's tissue matches
Possible complications include:
Infections. Severe bone marrow suppression is likely to accompany infections. This occurs when the bone marrow produces insufficient amounts of blood cells. Medications are frequently administered to treat and prevent diseases.
Low amounts of red blood cells (anaemia) and platelets (thrombocytopenia). These can be potentially harmful and even fatal. The majority of kids will require several transfusions of blood products.
Pain. Chemotherapy and radiation frequently result in mouth sores and gastrointestinal (GI) inflammation. Both pain medication and dental hygiene can be beneficial.
Vomiting, nausea, and diarrhoea. Chemotherapy, radiation, and gastrointestinal discomfort can all cause them. Until the diarrhoea stops and your kid can eat again, you may need to administer protein and calories via an intravenous (IV) line.
Excess fluid. This typically occurs when the kidneys are unable to process the high volume of intravenous fluids being administered. We will keep a careful eye out for any indications of fluid excess in your youngster. They will get regular urine measurements, blood tests, and frequent weight checks. To promote renal function and help the body eliminate excess fluid, medications may be administered.
Breathing issues. Graft-versus-host disease, haemorrhage, infection, airway inflammation, and fluid overload can all result in severe lung issues. Until problems are resolved, your youngster could require more oxygen to breathe.
Harm to organs. Fluid overload, chemotherapy, radiation, infection, and graft-versus-host disease can all result in either short-term (temporary) or long-term (permanent) liver and cardiac damage. To check for organ damage, your child's vital signs and blood will be closely monitored.
Graft failure. It's possible that the grafted cells won't proliferate in the bone marrow. This could be brought on by an infection, a recurrence of the illness, or an inadequate number of stem cells in the given bone marrow. Another bone marrow transplant may be used to treat graft failure.
GVHD, or graft-versus-host disease. GVHD can be severe and even fatal. It occurs when healthy cells in the recipient are attacked by the donor's immune cells. For GVHD, your child will be continuously monitored. Breathing issues, diarrhoea, fever, rash, skin changes, stomach pain, and impaired liver function are some of the symptoms. To lower this risk, medications will be administered to your child before the transplant.
Frequently Asked Questions (FAQ’s)
There live the blind texts separated they right at the coast of the Semantics.
Children receiving bone marrow transplants have a relatively high overall survival rate; many patients go on to lead everyday lives for the rest of their lives. The precise survival rates, however, may vary based on several factors, including the patient's circumstances, the type of ailment being treated, and the type of transplant (autologous vs. allogeneic).
For kids with severe illnesses, bone marrow transplantation (BMT), commonly referred to as a stem cell transplant, can save their lives and is usually regarded as safe. Although there are some hazards, for kids with illnesses such as childhood cancer, genetic problems, and immune system diseases, the advantages frequently exceed the risks.